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As a result of chromosomal abnormalities of the mother and / or father, a genetically defective embryo may occur. Balanced translocation is the most common chromosomal abnormality. If there is no abnormal chromosomal sequence in pairs, but chromosomal abnormalities are detected in the embryo, the family tree should be examined at this time. One of the treatment alternatives is preimplantation genetic screening. Here the biopsy is taken from the embryo formed by in vitro fertilization method and transferred to the mother which is seen as completely normal. Another option is to use donor sperm if the father has errors, and donor eggs if the mother has errors. Use of donor embryos should be an option if both have errors.
Uterine (uterine) abnormalities are another cause of recurrent pregnancy losses. Anatomically present disorders in the uterus are responsible for 15 percent of the cases. Such losses are often seen after the third month. The septum in the uterus most often causes these events. After three months, cervical insufficiency causes painless opening of cervix and loss of fetus. The only way to prevent this is to suture the cervix at 12 weeks without delay in diagnosis. The diagnosis of an anatomical disorder in the uterus is most clearly determined by hysteroscopy (examination of the inside of the uterus with light camera system) and hysterosalpingography (medicated uterine film). Hormonal disorders may be the cause of some recurrent pregnancy losses. Although controversial, progesterone insufficiency (luteal insufficiency) prevents the formation of the endometrial bed required for the fetus and causes miscarriage.
In the treatment, progesterone-containing drugs are given to the expectant mother. Recurrent fetal loss in uncontrolled diabetes and thyroid diseases
Why they are. These hormone disorders should be corrected with treatment. Some microbial agents have been implicated in early pregnancy losses. Ureoplasma, toxoplasma, chlamydia, listeria, herpes, neisseria, cytomegalovirus are some of them. Drug treatment should be performed as required.
Some collagen diseases also cause recurrent fetal losses. In addition, antibodies that cause damage by clotting the inner layers of the vessels are called “antiphospholipid syndrome.. Lupus anticoagulant and anticardiolipin antibody titers are evaluated in diagnosis. Low dose aspirin and / or heparin is used in these cases.
In cases with recurrent pregnancy loss, the woman's HLA is very similar to her partner. In addition, blocking antibody levels were found to be antileukocytotoxic.
antibody levels are also low. In short, the expectant mother's immunological response may not be sufficient to protect pregnancy. In these cases, leukocyte immunotherapy is applied and this treatment option is controversial. In half of the cases with recurrent pregnancy loss, no cause can be detected.